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In vitro approaches to assess the hazard of nanomaterials

Drasler, Barbara ; Sayre, Phil ; Steinhäuser, Klaus Günter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: NanoImpact, 2017, vol. 8, no. Supplement C, p. 99–116

The rapid development of engineered nanomaterials demands for a fast and reliable assessment of their health hazard potential. A plethora of experimental approaches have been developed and are widely employed in conventional toxicological approaches. However, the specific properties of nanomaterials such as smaller size but larger surface area, and high catalytic reactivity and distinctive...

Biodistribution of single and aggregated gold nanoparticles exposed to the human lung epithelial tissue barrier at the air-liquid interface

Durantie, Estelle ; Vanhecke, Dimitri ; Rodriguez-Lorenzo, Laura ; Delhaes, Flavien ; Balog, Sandor ; Septiadi, Dedy ; Bourquin, Joel ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Particle and Fibre Toxicology, 2017, vol. 14, p. 49

The lung represents the primary entry route for airborne particles into the human body. Most studies addressed possible adverse effects using single (nano)particles, but aerosolic nanoparticles (NPs) tend to aggregate and form structures of several hundreds nm in diameter, changing the physico-chemical properties and interaction with cells. Our aim was to investigate how aggregation might...

Taylor dispersion of nanoparticles

Urban, Dominic A. ; Milosevic, Ana M. ; Crippa, Federica ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Journal of Nanoparticle Research, 2017, vol. 19, no. 8, p. 287

The ability to detect and accurately characterize particles is required by many fields of nanotechnology, including materials science, nanotoxicology, and nanomedicine. Among the most relevant physicochemical properties of nanoparticles, size and the related surface-to-volume ratio are fundamental ones. Taylor dispersion combines three independent phenomena to determine particle size: optical...

Speckle-visibility spectroscopy of depolarized dynamic light scattering

Bossert, David ; Natterodt, Jens ; Urban, Dominic A. ; Weder, Christoph ; Petri-Fink, Alke

In: The Journal of Physical Chemistry B, 2017, vol. 121, no. 33, p. 7999–8007

We show that the statistical analysis of photon counts in depolarized dynamic light scattering experiments allows for the accurate characterization of the rotational Brownian dynamics of particles. Unlike photon correlation spectroscopy, the technique is accurate even at low temporal resolution and enables discontinuous data acquisition, which offers several advantages. To demonstrate the...

In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium

Montet-Abou, Karin ; Daire, Jean-Luc ; Hyacinthe, Jean-Noël ; Jorge-Costa, Manuel ; Grosdemange, Kerstin ; Mach, François ; Petri-Fink, Alke ; Hofmann, Heinrich ; Morel, Denis R. ; Vallée, Jean-Paul ; Montet, Xavier

In: European Heart Journal, 2010, vol. 31, no. 11, p. 1410-1420

Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field

Kamau, Sarah W. ; Hassa, Paul O. ; Steitz, Benedikt ; Petri-Fink, Alke ; Hofmann, Heinrich ; Hofmann-Amtenbrink, Margarethe ; von Rechenberg, Brigitte ; Hottiger, Michael O.

In: Nucleic Acids Research, 2006, vol. 34, no. 5, p. e40-e40

A Comparative Study of Different In Vitro Lung Cell Culture Systems to Assess the Most Beneficial Tool for Screening the Potential Adverse Effects of Carbon Nanotubes

Clift, Martin J. D. ; Endes, Carola ; Vanhecke, Dimitri ; Wick, Peter ; Gehr, Peter ; Schins, Roel P. F. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55-64

Magnetoliposomes: opportunities and challenges

Monnier, Christophe A. ; Burnand, David ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke

In: European Journal of Nanomedicine, 2014, vol. 6, no. 4, p. 201-215

Advanced human in vitro models to assess metal oxide nanoparticle-cell interactions

Wick, Peter ; Grafmueller, Stefanie ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: MRS Bulletin, 2014, vol. 39, no. 11, p. 984-989

Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro

Clift, Martin J.D. ; Frey, Sabine ; Endes, Carola ; Hirsch, Vera ; Kuhn, Dagmar A. ; Johnston, Blair D. ; Wick, Peter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: BioNanoMaterials, 2013, vol. 14, no. 3-4, p. 239-248