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Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia

Grimaldi, Mariagrazia ; Karaca, Melis ; Latini, Livia ; Brioudes, Estelle ; Schalch, Thomas ; Maechler, Pierre

In: Human Molecular Genetics, 2017, vol. 26, no. 18, p. 3453-3465

Development of Mice with Brain-Specific Deletion of Floxed Glud1 (Glutamate Dehydrogenase 1) Using Cre Recombinase Driven by the Nestin Promoter

Karaca, Melis ; Maechler, Pierre

In: Neurochemical Research, 2014, vol. 39, no. 3, p. 456-459

Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets

Brun, Thierry ; Li, Ning ; Jourdain, Alexis A. ; Gaudet, Pascale ; Duhamel, Dominique ; Meyer, Jérémy ; Bosco, Domenico ; Maechler, Pierre

In: Human Molecular Genetics, 2015, vol. 24, no. 18, p. 5270-5284

A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes

Casimir, Marina ; Andrade, Paula B. de ; Gjinovci, Asllan ; Montani, Jean-Pierre ; Maechler, Pierre ; Dulloo, Abdul G.

In: Nutrition & Metabolism, 2011, vol. 8, no. 2, p. 2

Current notions about mechanisms by which catch-up growth predisposes to later type 2 diabetes center upon those that link hyperinsulinemia with an accelerated rate of fat deposition (catch-up fat). Using a rat model of semistarvation-refeeding in which catch-up fat is driven solely by elevated metabolic efficiency associated with hyperinsulinemia, we previously reported that insulin-stimulated...