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Delay in feedback repression by Cryptochrome 1 is required for circadian clock function

Ukai-Tadenuma, Maki ; Yamada, Rikuhiro G. ; Xu, Haiyan ; Ripperger, Jürgen A. ; Liu, Andrew C. ; Ueda, Hiroki R.

In: Cell, 2011, vol. 144, no. 2, p. 268-281

Direct evidence for the requirement of delay in feedback repression in the mammalian circadian clock has been elusive. Cryptochrome 1 (Cry1), an essential clock component, displays evening-time expression and serves as a strong repressor at morning-time elements (E box/E′ box). In this study, we reveal that a combination of day-time elements (D box) within the...