In: Paläontologische Zeitschrift, 2007, vol. 81, no. 4, p. 406-415
- LESTER & HAND (1987) and LESTER et al. (1988) quoted
horse-shoe shaped prism cross sections as typical for
chiropterans....
- LESTER, K.S. & HAND, S.J. 1987....
- LESTER, K.S.; HAND, S.J. & VINCENT, F. 1988....
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In: Applied Microbiology and Biotechnology, 2007, vol. 73, no. 6, p. 1224-1232
- These C26containing PIs thus replace the essential function of
sphingolipids and structurally and functionally mimic
sphingolipids (Lester et al. 1993)....
- J Biol Chem
259:10150–10158
Dickson RC, Wells GB, Schmidt A, Lester RL (1990) Isolation of
mutant Saccharomyces cerevisiae strains that survive without
sphingolipids....
- Mol Cell Biol 10:2176–2181
Dickson RC, Sumanasekera C, Lester RL (2006) Functions and
metabolism of sphingolipids in Saccharomyces cerevisiae....
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In: The Journal of Theological Studies, 2015, vol. 66, no. 1, p. 322-325
- Edited by ALICE HUNT....
- The contribution by Alice Hunt, ‘The Importance of
ˆ
Context’, constitutes a raison d’etre for the volume....
- Lester L....
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In: FEMS Yeast Research, 2014, vol. 14, no. 5, p. 776–788
Humans and yeast possess alkaline ceramidases located in the early secretory pathway. Single deletions of the highly homologous yeast alkaline ceramidases YPC1 and YDC1 have very little genetic interactions or phenotypes. Here, we performed chemical-genetic screens to find deletions/conditions that would alter the growth of ypc1∆ydc1∆ double mutants. These screens...
- Dickson RC, Sumanasekera C & Lester RL (2006) Functions and metabolism of sphingolipids in Saccharomyces cerevisiae....
- Hanson BA & Lester RL (1980) The extraction of inositol-containing phospholipids and phosphatidylcholine from Saccharomyces cerevisiae and Neurospora crassa....
- Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL & Dickson RC (1997) Sphingolipid synthesis as a target for antifungal drugs....
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Titre de presse
140 ans, 41000 éditions
La Chaux-de-Fonds : L'Impartial, 1880
No spécimen [0] (27.12.1880); no 1 (1.1.1881) -
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In: Journal of Biological Chemistry, 2011, vol. 286, p. 6769-6779
In yeast, the inositolphosphorylceramides mostly contain C26:0 fatty acids. Inositolphosphorylceramides were considered to be important for viability because the inositolphosphorylceramide synthase AUR1 is essential. However, lcb1Δ cells, unable to make sphingoid bases and inositolphosphorylceramides, are viable if they harbor SLC1-1, a gain of function mutation in the...
- B., Lester, R....
- Lester, R....
- E., Lester, R....
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In: Journal of mammalian evolution, 2008, vol. 15, p. 37-58
- This structure seems to correspond to the prism “seam” described in many Mesozoic mammals and in a number of extant placental and marsupial taxa (e.g., chiropterans,
46
J Mammal Evol (2008) 15:37–58
dermopterans, humans, and Tarsipes; Lester and Hand 1987; Lester 1989; Lester and Koenigswald 1989; Wood and Stern 1997)....
- Cambridge, Cambridge University Press, pp 606–621 Lester KS (1989) Procerberus enamel—A missing link....
- Scanning Microsc 3:639–644 Lester KS, Hand SJ (1987) Chiropteran enamel structure....
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In: Molecular Microbiology, 2009, vol. 71, no. 6, p. 1523 - 1537
All mature Saccharomyces cerevisiae sphingolipids comprise inositolphosphorylceramides containing C26:0 or C24:0 fatty acids and either phytosphingosine or dihydrosphingosine. Here we analysed the lipid profile of lag1Δlac1Δ mutants lacking acyl-CoA-dependent ceramide synthesis, which require the reverse ceramidase activity of overexpressed Ydc1p for sphingolipid biosynthesis and viability....
- Dickson, R.C., and Lester, R.L. (2002) Sphingolipid functions in Saccharomyces cerevisiae....
- Dickson, R.C., Sumanasekera, C., and Lester, R.L. (2006) Functions and metabolism of sphingolipids in Saccharomyces cerevisiae....
- Most IPCs of wt cells contain hydroxylated C26 fatty acids (Smith and Lester, 1974)....
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In: Applied Microbiology and Biotechnology, 2007, vol. 73, no. 6, p. 1224-1232
Most integral membrane proteins are cotranslationally inserted into the lipid bilayer. In prokaryotes, membrane insertion of the nascent chain takes place at the plasma membrane, whereas in eukaryotes insertion takes place into the endoplasmatic reticulum. In both kingdoms of life, however, the same membrane that acquaints the newly born membrane protein also synthesizes the bilayer lipids...
- These C26containing PIs thus replace the essential function of
sphingolipids and structurally and functionally mimic
sphingolipids (Lester et al. 1993)....
- J Biol Chem
259:10150–10158
Dickson RC, Wells GB, Schmidt A, Lester RL (1990) Isolation of
mutant Saccharomyces cerevisiae strains that survive without
sphingolipids....
- Mol Cell Biol 10:2176–2181
Dickson RC, Sumanasekera C, Lester RL (2006) Functions and
metabolism of sphingolipids in Saccharomyces cerevisiae....
|
In: Biochemical Journal, 2007, vol. 401, no. 1, p. 205-216
Synthesis of VLCFAs (very long chain fatty acids) and biosynthesis of DHS (dihydrosphingosine) both are of vital importance for Saccharomyces cerevisiae. The bulk of VLCFAs and DHS are used for ceramide synthesis by the Lag1p (longevity-assurance gene 1)/Lac1p (longevity-assurance gene cognate 1)/Lip1p (Lag1p/Lac1p interacting protein) ceramide synthase. LAG1 and LAC1 are...
- W. and Lester, R....
- B., Lester, R....
- H., Lester, R....
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