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Université de Fribourg

A simple deep breathing test reveals altered cerebral autoregulation in type 2 diabetic patients

Brown, Clive M. ; Marthol, H. ; Zikeli, U. ; Ziegler, D. ; Hilz, M. J.

In: Diabetologia, 2008, vol. 51, no. 5, p. 756-761

Aims/hypothesis Patients with diabetes mellitus have an increased risk of stroke and other cerebrovascular complications. The purpose of this study was to evaluate the autoregulation of cerebral blood flow in diabetic patients using a simple method that could easily be applied to the clinical routine screening of diabetic patients.Methods We studied ten patients with type 2 diabetes mellitus and...

Université de Fribourg

Altered cerebral regulation in type 2 diabetic patients with cardiac autonomic neuropathy

Marthol, H. ; Brown, Clive Martin ; Zikeli, U. ; Ziegler, D. ; Dimitrov, N. ; Baltadzhieva, R. ; Hilz, M. J.

In: Diabetologia, 2006, vol. 49, no. 10, p. 2481-2487

Aims/hypothesis Assessment of cerebral regulation in diabetic patients is often problematic because of the presence of cardiac autonomic neuropathy. We evaluated the technique of oscillatory neck suction at 0.1 Hz to quantify cerebral regulation in diabetic patients and healthy control subjects.Subjects and methods In nine type 2 diabetic patients with cardiac autonomic neuropathy and 11...

Université de Fribourg

Effect of physical countermaneuvers on orthostatic hypotension in familial dysautonomia

Tutaj, M. ; Marthol, H. ; Berlin, D. ; Brown, Clive Martin ; Axelrod, F. B. ; Hilz, M. J.

In: Journal of Neurology, 2006, vol. 253, no. 1, p. 65-72

Familial dysautonomia (FD) patients frequently experience debilitating orthostatic hypotension. Since physical countermaneuvers can increase blood pressure (BP) in other groups of patients with orthostatic hypotension, we evaluated the effectiveness of countermaneuvers in FD patients.In 17 FD patients (26.4 ± 12.4 years, eight female), we monitored heart rate (HR), blood pressure (BP), cardiac...