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Associative learning and CA3–CA1 synaptic plasticity are impaired in D1r Null, Drd1a–/– mice and in hippocampal siRNA silenced Drd1a mice

Ortiz, Oskar ; Delgado-García, José María ; Espadas, Isabel ; Bahí, Amine ; Trullas, Ramón ; Dreyer, Jean-Luc ; Gruart, Agnès ; Moratalla, Rosario

In: The Journal of Neuroscience, 2010, vol. 30, no. 37, p. 12288-12300

Associative learning depends on multiple cortical and subcortical structures, including striatum, hippocampus, and amygdala. Both glutamatergic and dopaminergic neurotransmitter systems have been implicated in learning and memory consolidation. While the role of glutamate is well established, the role of dopamine and its receptors in these processes is less clear. In this study, we used two...