Université de Fribourg

The circadian molecular clock creates epidermal stem cell heterogeneity

Janich, Peggy ; Pascual, Gloria ; Merlos-Suárez, Anna ; Batlle, Eduard ; Ripperger, Jürgen ; Albrecht, Urs ; Obrietan, Karl ; Croce, Luciano Di ; Benitah, Salvador Aznar

In: Nature, 2011, p. -

Murine epidermal stem cells undergo alternate cycles of dormancy and activation, fuelling tissue renewal. However, only a subset of stem cells becomes active during each round of morphogenesis, indicating that stem cells coexist in heterogeneous responsive states. Using a circadian-clock reporter-mouse model, here we show that the dormant hair-follicle stem cell niche contains coexisting...