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SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death

Schlicher, Lisa ; Wissler, Manuela ; Preiss, Florian ; Brauns‐Schubert, Prisca ; Jakob, Celia ; Dumit, Veronica ; Borner, Christoph ; Dengjel, Jörn ; Maurer, Ulrich

In: EMBO reports, 2016, vol. 17, no. 10, p. 1485-1497

K63‐ and Met1‐linked ubiquitylation are crucial posttranslational modifications for TNF receptor signaling. These non‐degradative ubiquitylations are counteracted by deubiquitinases (DUBs), such as the enzyme CYLD, resulting in an appropriate signal strength, but the regulation of this process remains incompletely understood. Here, we describe an interaction partner of CYLD, SPATA2,...