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Université de Fribourg

Alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats

Boyer, Frederic ; Dreyer, Jean-Luc

In: European Journal of Neuroscience, 2007, vol. 26, no. 10, p. 2764-2776

The mesolimbic dopaminergic system is widely recognized to be critical to the neurobiology of cocaine reward and addiction. The neuronal protein, α-synuclein, is an important regulator in dopaminergic transmission. It interacts with the dopamine transporter, and regulates dopaminergic content, neurotransmission and synaptic strength of dopaminergic neurons. Alpha-synuclein levels are elevated in...

Université de Neuchâtel

Counter-intuitive developmental plasticity induced by host quality

Röder, Gregory ; Rahier, Martine ; Naisbit, Russell. E.

In: Proceedings of the Royal Society B, 2007, vol. 275, no. 1637, p. 879-885

Adaptation to different hosts plays a central role in the evolution of specialization and speciation in phytophagous insects and parasites, and our ability to experimentally rank hosts by their quality is critical to research to understand these processes. Here we provide a counter-intuitive example in which growth is faster on poor quality hosts. The leaf beetles Oreina elongata and...

Université de Fribourg

Differential patterns of functional and structural plasticity within and between inferior frontal gyri support training-induced improvements in inhibitory control proficiency

Chavan, Camille F. ; Mouthon, Michael ; Draganski, Bogdan ; Zwaag, Wietske van der ; Spierer, Lucas

In: Human Brain Mapping, 2015, vol. 36, no. 7, p. 2527–2543

Ample evidence indicates that inhibitory control (IC), a key executive component referring to the ability to suppress cognitive or motor processes, relies on a right-lateralized fronto-basal brain network. However, whether and how IC can be improved with training and the underlying neuroplastic mechanisms remains largely unresolved. We used functional and structural magnetic resonance imaging to...

Consortium of Swiss Academic Libraries

Disinhibition of neurite growth to repair the injured adult CNS: Focusing on Nogo

Gonzenbach, R. ; Schwab, M.

In: Cellular and Molecular Life Sciences, 2008, vol. 65, no. 1, p. 161-176

Université de Fribourg

The effect of learning on experimental evolution of resource preference in Drosophila melanogaster

Kawecki, Tadeusz J. ; Mery, Frederic

In: Evolution, 2004, vol. 58, p. 757-767

Learning is thought to be adaptive in variable environments, whereas constant, predictable environments are supposed to favor unconditional, genetically fixed responses. A dichotomous view of behavior as either learned or innate ignores a potential evolutionary interaction between the learned and innate components of a behavioral response. We addressed this interaction in the context of...