Université de Fribourg

Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

Foukas, Lazaros C. ; Claret, Marc ; Pearce, Wayne ; Okkenhaug, Klaus ; Meek, Stephen ; Peskett, Emma ; Sancho, Sara ; Smith, Andrew J. H. ; Withers, Dominic J. ; Vanhaesebroeck, Bart

In: Nature, 2006, vol. 441, p. 366-370

The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI(3)K) family form the backbone of an evolutionarily conserved signalling pathway; however, the roles of most PI(3)K isoforms in organismal physiology and disease are unknown. To delineate the role of p110, a ubiquitously expressed...