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Université de Fribourg

Multimodal communication in aphasia: perception and production of co-speech gestures during face-to-face conversation

Preisig, Basil C. ; Eggenberger, Noëmi ; Cazzoli, Dario ; Nyffeler, Thomas ; Gutbrod, Klemens ; Annoni, Jean-Marie ; Meichtry, Jurka R. ; Nef, Tobias ; Müri, René M.

In: Frontiers in Human Neuroscience, 2018, vol. 12, p. -

The role of nonverbal communication in patients with post-stroke language impairment (aphasia) is not yet fully understood. This study investigated how aphasic patients perceive and produce co-speech gestures during face-to-face interaction, and whether distinct brain lesions would predict the frequency of spontaneous co-speech gesturing. For this purpose, we recorded samples of conversations...

Université de Fribourg

Dorsolateral prefrontal transcranial direct current stimulation modulates language processing but does not facilitate overt second language word production

Radman, Narges ; Britz, Juliane ; Buetler, Karin ; Weekes, Brendan S. ; Spierer, Lucas ; Annoni, Jean-Marie

In: Frontiers in Neuroscience, 2018, vol. 12, p. -

Word retrieval in bilingual speakers partly depends on executive-control systems in the left prefrontal cortex - including dorsolateral prefrontal cortex (DLPFC). We tested the hypothesis that DLPFC modulates word production of words specifically in a second language (L2) by measuring the effects of anodal transcranial direct current stimulation (anodal-tDCS) over the DLPFC on picture naming...

Université de Fribourg

Comparison of a novel biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: 5-year outcomes of the randomized bioflow-ii trial

Lefèvre, Thierry ; Haude, Michael ; Neumann, Franz-Josef ; Stang, Karl ; Skurk, Carsten ; Slagboom, Ton ; Sabaté, Manel ; Goicolea, Javier ; Barragan, Paul ; Cook, Stéphane ; Macia, Jean-Christophe ; Windecker, Stephan

In: JACC: Cardiovascular Interventions, 2018, vol. 11, no. 10, p. 995–1002

ObjectivesThe authors aimed to compare long-term data of an ultrathin cobalt- chromium stent with passive silicon carbide coating and an active biodegradable polymer that releases sirolimus (O-SES) (Orsiro, BIOTRONIK, Bülach, Switzerland) with the durable polymer-based Xience Prime everolimus-eluting stent (X-EES) (Abbott Vascular, Santa Clara, California).BackgroundBiodegradable polymer...

Université de Fribourg

Distinct frequency specialization for detecting dark transients in humans and tree shrews

Khani, Abbas ; Mustafar, Faiz ; Rainer, Gregor

In: Cell Reports, 2018, vol. 23, no. 8, p. 2405–2415

Despite well-known privileged perception of dark over light stimuli, it is unknown to what extent this dark dominance is maintained when visual transients occur in rapid succession, for example, during perception of moving stimuli. Here, we address this question using dark and light transients presented at different flicker frequencies. Although both human participants and tree shrews...

Université de Fribourg

Genetic and Functional Characterization of an MCR-3-Like Enzyme-Producing Escherichia coli Isolate Recovered from Swine in Brazil

Kieffer, Nicolas ; Nordmann, Patrice ; Moreno, Andrea Micke ; Zanolli Moreno, Luisa ; Chaby, Richard ; Breton, Aude ; Tissières, Pierre ; Poirel, Laurent

In: Antimicrobial Agents and Chemotherapy, 2018, vol. 62, no. 7, p. e00278-18

A collection of 126 pigs was screened for carriage of colistin-resistant Enterobacteriaceae in a farm in Minas Gerais, Brazil. Out of this collection, eight colistin-resistant Escherichia coli isolates were recovered, including one from Minas Gerais State producing a new MCR-3 variant (MCR-3.12). Analysis of the lipopolysaccharide revealed that MCR-3.12 had a function similar to that of MCR-1...

Université de Fribourg

A culture medium for screening 16S rRNA methylase-producing pan-aminoglycoside resistant Gram-negative bacteria

Nordmann, Patrice ; Mazé, Alain ; Culebras, Esther ; Dobias, Jan ; Jayol, Aurélie ; Poirel, Laurent

In: Diagnostic Microbiology and Infectious Disease, 2018, vol. 91, no. 2, p. 118–122

The amikacin plus gentamicin-containing SuperAminoglycoside medium was developed for screening multiple-aminoglycoside resistance in Gram-negative bacteria (Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii). It was evaluated using aminoglycoside-susceptible (n=12) and aminoglycoside-resistant (n=59) Gram-negative isolates, including 16S rRNA methylase producers (n=20)....

Université de Fribourg

Engineered hybrid spider silk particles as delivery system for peptide vaccines

Lucke, Matthias ; Mottas, Inès ; Herbst, Tina ; Hotz, Christian ; Römer, Lin ; Schierling, Martina ; M.Herold, Heike ; Slotta, Ute ; Spinetti, Thibaud ; Scheibel, Thomas ; Winter, Gerhard ; Bourquin, Carole ; Engert, Julia

In: Biomaterials, 2018, vol. 172, p. 105–115

The generation of strong T-cell immunity is one of the main challenges for the development of successful vaccines against cancer and major infectious diseases. Here we have engineered spider silk particles as delivery system for a peptide-based vaccination that leads to effective priming of cytotoxic T-cells. The recombinant spider silk protein eADF4(C16) was fused to the antigenic peptide...

Université de Fribourg

Antarctica eye study: a prospective study of the effects of overwintering on ocular parameters and visual function

Stahl, Matthew H. ; Kumar, Alexander ; Lambert, Robert ; Stroud, Michael ; Macleod, David ; Bastawrous, Andrew ; Peto, Tunde ; Burton, Matthew J.

In: BMC Ophthalmology, 2018, vol. 18, no. 1, p. 149

In 2013 five polar explorers attempted to complete the first Trans-Antarctic Winter Traverse (TAWT). This study presents the ophthalmological findings for this group, who overwintered in Antarctica as part of the White Mars Human Science Protocol. Antarctic crews are exposed to extreme cold, chronic hypoxia and altered day-night cycles. Previous studies of Antarctic explorers have focused on...

Université de Fribourg

Isometric embeddings into Heisenberg groups

Balogh, Zoltán M. ; Fässler, Katrin ; Sobrino, Hernando

In: Geometriae Dedicata, 2018, vol. 195, no. 1, p. 163–192

We study isometric embeddings of a Euclidean space or a Heisenberg group into a higher dimensional Heisenberg group, where both the source and target space are equipped with an arbitrary left-invariant homogeneous distance that is not necessarily sub-Riemannian. We show that if all infinite geodesics in the target are straight lines, then such an embedding must be a homogeneous homomorphism....

Université de Fribourg

Phase segregation in supramolecular polymers based on telechelics synthesized via multicomponent reactions

Sehlinger, Ansgar ; Bartnick, Nikolai ; Gunkel, Ilja ; Meier, Michael A. R. ; Montero de Espinosa, Lucas

In: Macromolecular Chemistry and Physics, 2017, vol. 218, no. 22, p. 1700302

The properties of supramolecular polymers in the solid state are strongly dependent on the binding strength of the supramolecular motifs used; however, It has been previously shown that the nanostructure of supramolecular polymers plays an equally important role. Supramolecular polymers are commonly synthesized via end-group functionalization of low-glass transition telechelics with...