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Université de Fribourg

Bevacizumab specifically decreases elevated levels of circulating KIT+CD11b+ cells and IL-10 in metastatic breast cancer patients

Cattin, Sarah ; Fellay, Benoît ; Pradervand, Sylvain ; Trojan, Andreas ; Ruhstaller, Thomas ; Rüegg, Curzio ; Fürstenberger, Gregor

In: Oncotarget, 2016, vol. 7, no. 10, p. 11137–11150

Whether bevacizumab exerts its anti-tumor properties through systemic effects beyond local inhibition of angiogenesis and how these effects can be monitored in patients, remain largely elusive. To address these questions, we investigated bone marrow-derived cells and cytokines in the peripheral blood of metastatic breast cancer patients undergoing therapy with...

Université de Fribourg

Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling

Asparuhova, Maria B. ; Secondini, Chiara ; Rüegg, Curzio ; Chiquet-Ehrismann, Ruth

In: Molecular Oncology, 2015, vol. 9, no. 8, p. 1510–1527

Radiotherapy is a standard treatment after conservative breast cancer surgery. However, cancers relapsing within a previously irradiated area have an increased probability to metastasize. The mechanisms responsible for this aggressiveness remain unclear. Here, we used the clinically relevant 4T1 breast cancer model mimicking aggressive local relapse after radiotherapy to identify differences...

Université de Fribourg

An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models

Fagiani, Ernesta ; Bill, Ruben ; Pisarsky, Laura ; Ivanek, Robert ; Rüegg, Curzio ; Christofori, Gerhard

In: Angiogenesis, 2015, vol. 18, no. 3, p. 327–345

Tumor growth depends on the formation of new blood vessels (tumor angiogenesis) either from preexisting vessels or by the recruitment of bone marrow-derived cells. Despite encouraging results obtained with preclinical cancer models, the therapeutic targeting of tumor angiogenesis has thus far failed to deliver an enduring clinical response in cancer patients. One major obstacle for improving...

Université de Fribourg

Angiogenic activity of breast cancer patients’ monocytes reverted by combined use of systems modeling and experimental approaches

Guex, Nicolas ; Crespo, Isaac ; Bron, Sylvian ; Ifticene-Treboux, Assia ; Faes-van’t Hull, Eveline ; Kharoubi, Solange ; Liechti, Robin ; Werffeli, Patricia ; Ibberson, Mark ; Majo, Francois ; Nicolas, Michäel ; Laurent, Julien ; Garg, Abhishek ; Lehr, Khalil Zaman,Hans-Anton ; Stevenson, Brian J. ; Rüegg, Curzio ; Coukos, George ; Delaloye, Jean-François ; Xenarios, Ioannis ; Doucey, Marie-Agnès

In: PLoS Comput Biol, 2015, vol. 11, no. 3, p. e1004050

Angiogenesis plays a key role in tumor growth and cancer progression. TIE-2-expressing monocytes (TEM) have been reported to critically account for tumor vascularization and growth in mouse tumor experimental models, but the molecular basis of their pro-angiogenic activity are largely unknown. Moreover, differences in the pro-angiogenic activity between blood circulating and tumor infiltrated TEM...

Université de Fribourg

A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer

Monaco, Alessandra ; Michelin, Olivier ; Prior, John ; Rüegg, Curzio ; Scapozza, Leonardo ; Seimbille, Yann

In: Alimentary Pharmacology & Therapeutics, 2014, vol. 39, no. 5, p. 507–517

Arginine–glycine–aspartic acid (RGD)-containing peptides have been traditionally used as PET probes to noninvasively image angiogenesis, but recently, small selective molecules for α₅β₁ integrin receptor have been developed with promising results. Sixty-one antagonists were screened, and tert-butyl...

Université de Fribourg

Inhibition of cell migration and invasion mediated by the TAT-RasGAP317–326 peptide requires the DLC1 tumor

Barras, D ; Lorusso, Girieca ; Rüegg, Curzio ; Widmann, Christian

In: Oncogene, 2014, p. -

TAT-RasGAP317–326, a peptide corresponding to the 317–326 sequence of p120 RasGAP coupled with a cell-permeable TAT-derived peptide, sensitizes the death response of various tumor cells to several anticancer treatments. We now report that this peptide is also able to increase cell adherence, prevent cell migration and inhibit matrix invasion. This is accompanied by a marked...

Université de Fribourg

Fragment N2, a caspase-3-generated RasGAP fragment, inhibits breast cancer metastatic progression

Barras, David ; Lorusso, Girieca ; Lhermitte, Benoît ; Viertl, David ; Rüegg, Curzio ; Widmann, Christian

In: International Journal of Cancer, 2014, p. -

The p120 RasGAP protein negatively regulates Ras via its GAP domain. RasGAP carries several other domains that modulate several signaling molecules such as Rho. RasGAP is also a caspase-3 substrate. One of the caspase-3-generated RasGAP fragments, corresponding to amino acids 158–455 and called fragment N2, was previously reported to specifically sensitize cancer cells to death induced by...

Université de Fribourg

Synthesis and in vitro evaluation of a novel radioligand for αvβ3 integrin receptor imaging: [¹⁸F]FPPA-c(RGDfK)

Monaco, Alessandra ; Zoete, Vincent ; Alghisi, Gian Carlo ; Rüegg, Curzio ; Michelin, Olivier ; Prior, John ; Scapozza, Leonardo ; Seimbille, Yann

In: Bioorganic & Medicinal Chemistry Letters, 2013, vol. 23, no. 22, p. 6068–6072

The development of RGD-based antagonist of αvβ3 integrin receptor has enhanced the interest in PET probes to image this receptor for the early detection of cancer, to monitor the disease progression and the response to therapy. In this work, a novel prosthetic group (N-(4-fluorophenyl)pent-4-ynamide or FPPA) for the 18F-labeling of an αvβ3 selective RGD-peptide was successfully prepared....

Université de Fribourg

A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer

Nichita, C. ; Ciarloni, L. ; Monnier-Benoit, S. ; Hosseinian, S. ; Dorta, G. ; Rüegg, Curzio

In: Alimentary Pharmacology & Therapeutics, 2014, vol. 39, no. 5, p. 507–517

Background: Early detection and treatment of colorectal adenomatous polyps (AP) and colorectal cancer (CRC) is associated with decreased mortality for CRC. However, accurate, non-invasive and compliant tests to screen for AP and early stages of CRC are not yet available. A blood-based screening test is highly attractive due to limited invasiveness and high acceptance rate among patients.Aim: To...

Université de Fribourg

The αVβ3/αVβ5 integrin inhibitor cilengitide augments tumor response to melphalan isolated limb perfusion in a sarcoma model

Hagen, Timo L.M. ten ; Seynhaeve, Ann L.B. ; Wiel-Ambagtsheer, Gisela aan de ; Bruijn, Ernst A. de ; Tiel, Sandra T. van ; Rüegg, Curzio ; Meyring, Michael ; Grell, Matthias ; Goodman, Simon L. ; Eggermont, Alexander M.M.

In: International Journal of Cancer, 2012, p. -

Isolated limb perfusion (ILP) with melphalan and tumor necrosis factor (TNF)-α is used to treat bulky, locally advanced melanoma and sarcoma. However, TNF toxicity suggests a need for better-tolerated drugs. Cilengitide (EMD 121974), a novel cyclic inhibitor of alpha-V integrins, has both anti-angiogenic and direct anti-tumor effects and is a possible alternative to TNF in ILP. In this study,...