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Université de Fribourg

Jagged1 is altered in alzheimer’s disease and regulates spatial memory processing

Marathe, Swananda ; Jaquet, Muriel ; Annoni, Jean-Marie ; Alberi, Lavinia

In: Frontiers in Cellular Neuroscience, 2017, vol. 11, p. -

Notch signaling plays an instrumental role in hippocampus-dependent memory formation and recent evidence indicates a displacement of Notch1 and a reduction its activity in hippocampal and cortical neurons from Alzheimer's disease (AD) patients. As Notch activation depends on ligand availability, we investigated whether Jagged1 expression was altered in brain specimen of AD patients. We found...

Université de Fribourg

Successful neuropsychological rehabilitation in a patient with Cerebellar Cognitive Affective Syndrome

Ruffieux, N. ; Colombo, Françoise ; Gentaz, E. ; Annoni, Jean-Marie ; Chouiter, Leila ; Roulin Hefti, S. ; Ruffieux, A. ; Bihl, T.

In: Applied Neuropsychology: Child, 2017, vol. 6, no. 2, p. 180–188

The objective of this case study was to describe the neuropsychological rehabilitation of a 16-year-old patient who presented a Cerebellar Cognitive Affective Syndrome (CCAS) following a bilateral cerebellar hemorrhage. The patient presented severe and diffuse cognitive deficits, massive behavioral disorders, and emotion regulation difficulties. The cognitive rehabilitation was performed in...

Université de Fribourg

Neural correlates of maladaptive pain behavior in chronic neck pain - a single case control fMRI study

Beinert, Konstantin ; Mouthon, Audrey ; Keller, Martin ; Mouthon, Michael ; Annoni, Jean-Marie ; Taube, Wolfgang

In: Pain Physician, 2017, vol. 20, no. 1, p. E115–E125

Chronic neck pain patients display functional impairments like decreased range of motion, decreased strength, and reduced sensorimotor function. In patients without structural damage, the reason for the persistence of pain is not well understood. Therefore, it is assumed that in chronic pain states, memory processes play an important role. We have now detected and tested a patient that might...

Université de Fribourg

Screening for language disorders in stroke: german validation of the language screening test (last)

Koenig-Bruhin, M. ; Vanbellingen, Tim ; Schumacher, Rahel ; Pflugshaupt, T. ; Annoni, Jean-Marie ; Müri, René M. ; Bohlhalter, Stephan ; Nyffeler, Thomas

In: Cerebrovascular Diseases Extra, 2016, vol. 6, no. 1, p. 27–31

Background: Screening of aphasia in acute stroke is crucial for directing patients to early language therapy. The Language Screening Test (LAST), originally developed in French, is a validated language screening test that allows detection of a language deficit within a few minutes. The aim of the present study was to develop and validate two parallel German versions of the LAST. Methods: The...

Université de Fribourg

The role of the cognitive control system in recovery from bilingual aphasia: a multiple single-case fMRI study

Radman, Narges ; Mouthon, Michael ; Pietro, Marie Di ; Gaytanidis, Chrisovalandou ; Leemann, Beatrice ; Abutalebi, Jubin ; Annoni, Jean-Marie

In: Neural Plasticity, 2016, vol. 2016, p. e8797086

Aphasia in bilingual patients is a therapeutic challenge since both languages can be impacted by the same lesion. Language control has been suggested to play an important role in the recovery of first (L1) and second (L2) language in bilingual aphasia following stroke. To test this hypothesis, we collected behavioral measures of language production (general aphasia evaluation and picture...

Université de Fribourg

Language specificity of lexical-phonological therapy in bilingual aphasia: A clinical and electrophysiological study

Radman, Narges ; Spierer, Lucas ; Laganaro, Marina ; Annoni, Jean-Marie ; Colombo, Françoise

In: Neuropsychological Rehabilitation, 2016, vol. 26, no. 4, p. 532–557

Based on findings for overlapping representations of bilingual people's first (L1) and second (L2) languages, unilingual therapies of bilingual aphasia have been proposed to benefit the untrained language. However, the generalisation patterns of intra- and cross-language and phonological therapy and their neural bases remain unclear. We tested whether the effects of an intensive...