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In vivo gene silencing of CD81 by lentiviral expression of small interference RNAs suppresses cocaine-induced behaviour

Bahi, Amine ; Boyer, Frederic ; Kolira, Manoj ; Dreyer, Jean-Luc

In: Journal of Neurochemistry, 2005, vol. 92(5), p. 1243

The tetraspanin CD81 is induced in the mesolimbic dopaminergic pathway after cocaine administration. To further investigate its role, a regulatable lentivirus (Lenti-CD81) bearing the CD81 gene under the control of a tetracycline-inducible promoter and lentiviruses expressing short hairpin RNA (shRNA) targeted against CD81 (Lenti-CD81-shRNAs) have been prepared. Infection of HEK293T cells in...

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CD81-induced behavioural changes during chronic cocaine administration: in vivo gene delivery with regulatable lentivirus

Bahi, Amine ; Boyer, Frederic ; Kafri, Tal ; Dreyer, Jean-Luc

In: European Journal of Neuroscience, 2004, vol. 19, p. 1621-1633

CD81, a tetraspanin transmembrane protein involved in cell adhesion, is up-regulated in the mesolimbic dopaminergic pathway 24 h following acute administration of high doses of cocaine [Brenz-Verca et al., (2001) Mol. Cell. Neurosci., 17, 303-316]. Further evidence consecutive with this observation and based on microarray analysis are presented here. In addition, a regulatable lentivirus was...

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