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Université de Neuchâtel

Estimation of a counterfactual wage distribution using survey data

Anastasiade, Mihaela-Cãtãlina ; Tillé, Yves (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

De nos jours, la discrimination salariale basée sur le sexe est un sujet débattu. Bien que la discrimination salariale soit interdite par la Déclaration universelle des droits de l’homme, des études montrent que les femmes sont systématiquement payées moins que les hommes. La discrimination salariale se produit quand deux groupes partageant les mêmes caractéristiques et remplissant les...

Université de Neuchâtel

Social behaviour, stress and parasites : comparing free-ranging wolves in Yellowstone (USA), Abruzzo (Italy) and Mercantour (France) national parks

Molnar, Barbara ; Betschart, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2012.

Occupant autrefois la majeure partie de l’hémisphère nord, les populations de loups (Canis lupus) ont disparu dans une importante partie de leur aire de distribution initiale, consécutivement à la persécution humaine. Suite à la protection de l’espèce, le carnivore a récemment étendu son aire de distribution, par des mouvements de dispersion ou au travers de programmes de...

Université de Fribourg

The impact of ESCRT on Aβ1-42 induced membrane lesions in a yeast model for Alzheimer’s disease

Fruhmann, Gernot ; Marchal, Christelle ; Vignaud, Hélène ; Verduyckt, Mathias ; Talarek, Nicolas ; De Virgilio, Claudio ; Winderickx, Joris ; Cullin, Christophe

In: Frontiers in Molecular Neuroscience, 2018, vol. 11, p. -

Aβ metabolism plays a pivotal role in Alzheimer’s disease. Here, we used a yeast model to monitor Aβ42 toxicity when entering the secretory pathway and demonstrate that processing in, and exit from the endoplasmic reticulum (ER) is required to unleash the full Aβ42 toxic potential. Consistent with previously reported data, our data suggests that Aβ42 interacts with mitochondria, thereby...

Université de Fribourg

Packmem: a versatile tool to compute and visualize interfacial packing defects in lipid bilayers

Gautier, Romain ; Bacle, Amélie ; Tiberti, Marion L. ; Fuchs, Patrick F. ; Vanni, Stefano ; Antonny, Bruno

In: Biophysical Journal, 2018, vol. 115, no. 3, p. 436–444

The analysis of the structural organization of lipid bilayers is generally performed across the direction normal to the bilayer/water interface, whereas the surface properties of the bilayer at the interface with water are often neglected. Here, we present PackMem, a bioinformatic tool that performs a topographic analysis of the bilayer surface from various molecular dynamics simulations....

Université de Fribourg

Two pairs of drosophila central brain neurons mediate larval navigational strategies based on temporal light information processing

Humberg, Tim-Henning ; Sprecher, Simon G.

In: Frontiers in Behavioral Neuroscience, 2018, vol. 12, p. -

Some animals are attracted by sun light, others are highly repulsed by it. Especially for slowly moving animals, such as Drosophila larvae, direct sunlight may be perceived as noxious stimulus as it increases the risk of desiccation, DNA-damaging by UV-light and exposure to predators. For several reasons, model organisms like Drosophila larvae are well-suited for investigating how light cues...

Université de Fribourg

Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit

Widmer, Yves F ; Fritsch, Cornelia ; Jungo, Magali M ; Almeida, Silvia ; Egger, Boris ; Sprecher, Simon G

In: eLife, 2018, vol. 7, p. e39196

Lasting changes in gene expression are critical for the formation of long-term memories (LTMs), depending on the conserved CrebB transcriptional activator. While requirement of distinct neurons in defined circuits for different learning and memory phases have been studied in detail, only little is known regarding the gene regulatory changes that occur within these neurons. We here use the...

Université de Fribourg

Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants

Wilbers, Ruud H. P. ; Schneiter, Roger ; Holterman, Martijn H. M. ; Drurey, Claire ; Smant, Geert ; Asojo, Oluwatoyin A. ; Maizels, Rick M. ; Lozano-Torres, Jose L.

In: PLOS Pathogens, 2018, vol. 14, no. 10, p. e1007300

Despite causing considerable damage to host tissue at the onset of parasitism, invasive helminths establish remarkably persistent infections in both animals and plants. Secretions released by these obligate parasites during host invasion are thought to be crucial for their persistence in infection. Helminth secretions are complex mixtures of molecules, most of which have unknown molecular...

Université de Fribourg

The ongoing naturalisation of Eucalyptus spp. in the Mediterranean Basin: new threats to native species and habitats

Badalamenti, Emilio ; Cusimano, D. ; Mantia, Tommaso La ; Pasta, Salvatore ; Romano, S. ; Troia, Angelo ; Ilardi, V.

In: Australian Forestry, 2018, vol. 81, no. 4, p. 239–249

The genus Eucalyptus has been widely introduced into many regions of the world outside its native range and has become invasive in some Mediterranean biomes (e.g. in southern Africa and California). In the Mediterranean Basin and Europe, eucalypts were introduced at the end of the 18th century. However, natural regeneration events in these regions are recent in time and limited in terms of...

Université de Fribourg

Conventional and emerging roles of the energy sensor Snf1/AMPK in Saccharomyces cerevisiae

Coccetti, Paola ; Nicastro, Raffaele ; Tripodi, Farida

In: Microbial Cell, 2018, vol. 5, no. 11, p. 482–494

All proliferating cells need to match metabolism, growth and cell cycle progression with nutrient availability to guarantee cell viability in spite of a changing environment. In yeast, a signaling pathway centered on the effector kinase Snf1 is required to adapt to nutrient limitation and to utilize alternative carbon sources, such as sucrose and ethanol. Snf1 shares evolutionary conserved...