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Université de Fribourg

Taylor dispersion of nanoparticles

Urban, Dominic A. ; Milosevic, Ana M. ; Crippa, Federica ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Journal of Nanoparticle Research, 2017, vol. 19, no. 8, p. 287

The ability to detect and accurately characterize particles is required by many fields of nanotechnology, including materials science, nanotoxicology, and nanomedicine. Among the most relevant physicochemical properties of nanoparticles, size and the related surface-to-volume ratio are fundamental ones. Taylor dispersion combines three independent phenomena to determine particle size: optical...

Université de Fribourg

Speckle-visibility spectroscopy of depolarized dynamic light scattering

Bossert, David ; Natterodt, Jens ; Urban, Dominic A. ; Weder, Christoph ; Petri-Fink, Alke

In: The Journal of Physical Chemistry B, 2017, vol. 121, no. 33, p. 7999–8007

We show that the statistical analysis of photon counts in depolarized dynamic light scattering experiments allows for the accurate characterization of the rotational Brownian dynamics of particles. Unlike photon correlation spectroscopy, the technique is accurate even at low temporal resolution and enables discontinuous data acquisition, which offers several advantages. To demonstrate the...

Accès public à partir du 1 nov. 2019
Consortium of Swiss Academic Libraries

Advanced human in vitro models to assess metal oxide nanoparticle-cell interactions

Wick, Peter ; Grafmueller, Stefanie ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: MRS Bulletin, 2014, vol. 39, no. 11, p. 984-989

Université de Fribourg

Cellular shuttles: monocytes/macrophages exhibit transendothelial transport of nanoparticles under physiological flow

Moore, Thomas L. ; Hauser, Daniel ; Gruber, Thomas ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke ; Lyck, Ruth

In: ACS Applied Materials & Interfaces, 2017, vol. 9, no. 22, p. 18501–18511

A major hurdle in the development of biomedical nanoparticles (NP) is understanding how they interact with complex biological systems and navigate biological barriers to arrive at pathological targets. It is becoming increasingly evident that merely controlling particle physicochemical properties may not be sufficient to mediate particle biodistribution in dynamic environments. Thus,...

Université de Fribourg

Quantifying nanoparticle cellular uptake: which method is best?

Drasler, Barbara ; Vanhecke, Dimitri ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Nanomedicine, 2017, vol. 12, no. 10, p. 1095–1099

As the range of engineered nanoparticles (NPs) designed as specific carriers increases, for example for cell targeting and drug delivery, the question on how many NPs are interacting or are taken up by cells is becoming increasingly important for any potential biomedical application. On one hand, the delivered dose of such NPs to the targeted cells is a key parameter in the assessment of...

Université de Fribourg

Human asthmatic bronchial cells are more susceptible to subchronic repeated exposures of aerosolized carbon nanotubes at occupationally relevant doses than healthy cells

Chortarea, Savvina ; Barosova, Hana ; Clift, Martin James David ; Wick, Peter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2017, p. -

Although acute pulmonary toxicity of carbon nanotubes (CNTs) has been extensively investigated, the knowledge of potential health effects following chronic occupational exposure is currently limited and based only upon in vivo approaches. Our aim was to realistically mimic subchronic inhalation of multiwalled CNTs (MWCNTs) in vitro, using the air–liquid interface cell exposure (ALICE)...