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Université de Fribourg

Klebsiella pneumoniae co-producing KPC and RmtG, finally targeting Switzerland

Mancini, Stefano ; Poirel, Laurent ; Corthesy, Myriam ; Greub, Gilbert ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2017, p. -

A carbapenem- and pan-aminoglycoside-resistant Klebsiella pneumoniae strain was isolated from a Brazilian patient hospitalized in a Swiss hospital.The clinical isolate carried genes encoding the KPC-2 carbapenemase and the RmtG 16S rRNA methyltransferase.This is the first report of a carbapenem-resistant K. pneumoniae producing RmtG in Europe

Université de Fribourg

High Rate of MCR-1–Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal

Kieffer, Nicolas ; Aires-de-Sousa, Marta ; Nordmann, Patrice ; Poirel, Laurent

In: Emerging Infectious Diseases, 2017, vol. 23, no. 12, p. 2023–2029

The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1–producing...

Université de Fribourg

Emergence of an MDR Klebsiella pneumoniae ST231 producing OXA-232 and RmtF in Switzerland

Mancini, Stefano ; Poirel, Laurent ; Tritten, Marie-Lise ; Lienhard, Reto ; Bassi, Cécile ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2017, p. -

The increasing incidence of carbapenem-resistant Klebsiella pneumoniae is a major challenge to public health. Despite the fact that the prevalence of carbapenemases among carbapenem-resistant K. pneumoniae varies geographically, the incidence of OXA-48-like enzymes has soared in recent years and is particularly high in some European countries, such as Spain and France (74% and 78% among ...

Université de Fribourg

Ceftazidime/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae

Jayol, Aurélie ; Nordmann, Patrice ; Poirel, Laurent ; Dubois, Véronique

In: Journal of Antimicrobial Chemotherapy, 2017, p. -

The spread of carbapenemase-producing Klebsiella pneumoniae is a major public health concern since such isolates are basically resistant to most available antibiotics, including β-lactams, fluoroquinolones and aminoglycosides.1 Infections due to carbapenemase-producing K. pneumoniae are therefore commonly treated with a regimen containing colistin.1 However, acquired resistance to colistin...

Université de Fribourg

Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014

Potron, Ana?s ; Bernabeu, Sandrine ; Cuzon, Gaëlle ; Ponti?s, Valérie ; Blanchard, Hervé ; Seringe, Elise ; Naas, Thierry ; Nordmann, Patrice ; Dortet, Laurent

In: Eurosurveillance, 2017, vol. 22, no. 49, p. 17-00048

OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204- positive enterobacterial isolates (n = 29) recovered in France between...

Université de Fribourg

Key features of mcr-1-bearing plasmids from Escherichia coli isolated from humans and food

Zurfluh, Katrin ; Nüesch-Inderbinen, Magdalena ; Klumpp, Jochen ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 91

Mcr-1-harboring Enterobacteriaceae are reported worldwide since their first discovery in 2015. However, a limited number of studies are available that compared full-length plasmid sequences of human and animal origins.

Université de Fribourg

High-level resistance to colistin mediated by various mutations in the crrb gene among carbapenemase-producing klebsiella pneumoniae

Jayol, Aurélie ; Nordmann, Patrice ; Brink, Adrian ; Villegas, Maria-Virginia ; Dubois, Véronique ; Poirel, Laurent

In: Antimicrobial Agents and Chemotherapy, 2017, vol. 61, no. 11, p. e01423-17

Mutations in crrAB genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin- resistant Klebsiella pneumoniae isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB...

Université de Fribourg

Diagnosing antimicrobial resistance

Burnham, Carey-Ann D. ; Leeds, Jennifer ; Nordmann, Patrice ; O'Grady, Justin ; Patel, Jean

In: Nature Reviews Microbiology, 2017, vol. 15, no. 11, p. nrmicro.2017.103

Antimicrobial resistance constitutes a global health burden and research efforts are aimed at combatting the emergence of resistant microorganisms. In this Viewpoint article, several experts in the field discuss the role that rapid diagnostic tests have in managing the challenge of antimicrobial resistance, the drawbacks of current diagnostic methods, novel diagnostic strategies, and how such...

Université de Fribourg

CHROMagar mSuperCARBA and RAPIDEC® Carba NP test for detection of carbapenemase-producing Enterobacteriaceae

Garcia-Quintanilla, Meritxell ; Poirel, Laurent ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2017, p. -

A novel chromogenic medium CHROMagar mSuperCARBA was evaluated to detect carbapenem-resistant Gram-negatives. This medium is as sensitive and as specific as the SUPERCARBA medium for detecting KPC, MBL and OXA-48-type producers (100% and 100%, respectively) and is compatible with subsequent testing of carbapenemase activity using the RAPIDEC® CARBA NP.