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Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function

de Andrade, P. ; Rubi, B. ; Frigerio, F. ; van den Ouweland, J. ; Maassen, J. ; Maechler, P.

In: Diabetologia, 2006, vol. 49, no. 8, p. 1816-1826

Peroxidases have more functions than a Swiss army knife

Passardi, F. ; Cosio, C. ; Penel, C. ; Dunand, C.

In: Plant Cell Reports, 2005, vol. 24, no. 5, p. 255-265

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis' mechanism involving reactive oxygen species and PGC-1

Bouitbir, Jamal ; Charles, Anne-Laure ; Echaniz-Laguna, Andoni ; Kindo, Michel ; Daussin, Frédéric ; Auwerx, Johan ; Piquard, François ; Geny, Bernard ; Zoll, Joffrey

In: European Heart Journal, 2012, vol. 33, no. 11, p. 1397-1407

Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury

Spescha, Remo D. ; Shi, Yi ; Wegener, Susanne ; Keller, Stephan ; Weber, Bruno ; Wyss, Matthias M. ; Lauinger, Nadine ; Tabatabai, Ghazaleh ; Paneni, Francesco ; Cosentino, Francesco ; Hock, Christoph ; Weller, Michael ; Nitsch, Roger M. ; Lüscher, Thomas F. ; Camici, Giovanni G.

In: European Heart Journal, 2013, vol. 34, no. 2, p. 96-103

Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: Implications for diet-induced obesity

Mundy, Alexa L. ; Haas, Elvira ; Bhattacharya, Indranil ; Widmer, Corinne C. ; Kretz, Martin ; Hofmann-Lehmann, Regina ; Minotti, Roberta ; Barton, Matthias

In: Cardiovascular Research, 2007, vol. 73, no. 2, p. 368-375

The NPR1-dependent salicylic acid signalling pathway is pivotal for enhanced salt and oxidative stress tolerance in Arabidopsis

Jayakannan, Maheswari ; Bose, Jayakumar ; Babourina, Olga ; Shabala, Sergey ; Massart, Amandine ; Poschenrieder, Charlotte ; Rengel, Zed

In: Journal Of Experimental Botany, 2015, vol. 66, no. 7, p. 1865-1875

The cuticle and plant defense to pathogens

Metraux, Jean-Pierre ; Serrano, Mario ; Torres, Martha ; Coluccia, Fania ; L’Haridon, Floriane

In: Frontiers in Plant Science, 2014, vol. 5, p. 274

The cuticle provides a physical barrier against water loss and protects against irradiation, xenobiotics and pathogens. Components of the cuticle are perceived by invading fungi and activate developmental processes during pathogenesis. In addition, cuticle alterations of various types induce a syndrome of reactions that often results in resistance to necrotrophs. This article reviews the current...

Production of reactive oxygen species and wound-induced resistance in Arabidopsis thaliana against Botrytis cinerea are preceded and depend on a burst of calcium

Beneloujaephajri, Emna ; Costa, Alex ; L’Haridon, Floriane ; Métraux, Jean-Pierre ; Binda, Matteo

In: BMC Plant Biology, 2013, vol. 13, no. 1, p. 160

Background: Wounded leaves of Arabidopsis thaliana produce reactive oxygen species (ROS) within minutes after wounding and become resistant to the pathogenic fungus Botrytis cinerea at a local level. This fast response of the plants to the wound is called wound-induced resistance (WIR). However the molecular mechanisms of this response and the signal cascade between the wound and ROS production...

A role for β-sitosterol to stigmasterol conversion in plant–pathogen interactions

Griebel, Thomas ; Zeier, Jürgen

In: The Plant Journal, 2010, vol. 63, no. 2, p. 254–268

Upon inoculation with pathogenic microbes, plants induce an array of metabolic changes that potentially contribute to induced resistance or even enhance susceptibility. When analysing leaf lipid composition during the Arabidopsis thaliana–Pseudomonas syringae interaction, we found that accumulation of the phytosterol stigmasterol is a significant plant metabolic process that occurs upon...

Role of JNK activation in pancreatic β-cell death by streptozotocin

Cheon, Hwanju ; Cho, Jae Min ; Kim, Sunshin ; Baek, Seung-Hoon ; Lee, Moon-Kyu ; Kim, Kwang-Won ; Yu, Seong-Woon ; Solinas, Giovanni ; Kim, Soung Soo ; Lee, Myung-Shik

In: Molecular and Cellular Endocrinology, 2010, vol. 321, no. 2, p. 131-137

c-Jun N-terminal kinase (JNK) is activated by cellular stress and plays critical roles in diverse types of cell death. However, role of JNK in β-cell injury is obscure. We investigated the role for JNK in streptozotocin (STZ)-induced β-cell death. STZ induced JNK activation in insulinoma or islet cells. JNK inhibitors attenuated insulinoma or islet cell death by STZ. STZ-induced JNK activation...