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Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Vogl, Claus ; Flatt, Thomas ; Fuhrmann, Bernd ; Hofmann, Elisabeth ; Wallner, Barbara ; Stiefvater, Rita ; Kovarik, Pavel ; Strobl, Birgit ; Müller, Mathias

In: BMC Genomics, 2010, vol. 11, no. 199, p. 1-19

Background: Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysaccharide (LPS), and Tyk2 deficient macrophages fail to efficiently induce interferon alpha/beta after LPS treatment....

Evolution of longevity improves immunity in Drosophila

Fabian, Daniel K. ; Garschall, Kathrin ; Klepsatel, Peter ; Santos-Matos, Gonçalo ; Sucena, Élio ; Kapun, Martin ; Lemaitre, Bruno ; Schlötterer, Christian ; Arking, Robert ; Flatt, Thomas

In: Evolution Letters, 2018, vol. 2, no. 6, p. 567–579

Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin signaling as a major regulator of longevity, yet whether standing variation in this pathway underlies microevolutionary changes in...

Structural aspects of molecular recognition in the immune system. Part I: Acquired immunity (IUPAC Technical Report)

Templeton, Douglas M. ; Moehle, Kerstin

In: Pure and Applied Chemistry, 2014, vol. 86, no. 10, p. 1435-1481

Effect of gut active carbohydrates on plasma IgG concentrations in piglets and calves

Lazarevic, M. ; Spring, P. ; Shabanovic, M. ; Tokic, V. ; Tucker, L. A.

In: animal, 2010, vol. 4, no. 6, p. 938-943

9. Effect of insecticide-treated bed nets on haemoglobin values, prevalence and multiplicity of infection with Plasmodium falciparum in a randomized controlled trial in Tanzania

Fraser-Hurt, N. ; Felger, I. ; Edoh, D. ; Steiger, S. ; Mashaka, M. ; Masanja, H. ; Smith, T. ; Mbena, F. ; Beck, H.-P

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 1999, vol. 93, no. Supplement_1, p. 47-51

Persistence of Bartonella spp. stealth pathogens: from subclinical infections to vasoproliferative tumor formation

Pulliainen, Arto T. ; Dehio, Christoph

In: FEMS Microbiology Reviews, 2012, vol. 36, no. 3, p. 563-599

Cytokine and immunoglobulin subclass responses of rats to infection with Eimeria nieschulzi

Smith, N. C. ; Ovington, K. S. ; Deplazes, P. ; Eckert, J.

In: Parasitology, 1995, vol. 111, no. 1, p. 51-57

6. Multiple Plasmodium falciparum infections in Tanzanian infants

Felger, I. ; Smith, T. ; Edoh, D. ; Kitua, A. ; Alonso, P. ; Tanner, M. ; Beck, H.-P

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 1999, vol. 93, no. Supplement_1, p. 29-34

The functional costs and benefits of dietary restriction in Drosophila

Burger, Joep M. S. ; Hwangbo, Dae Sung ; Corby-Harris, Vanessa ; Promislow, Daniel E. L.

In: Aging Cell, 2007, vol. 6, no. 1, p. 63–71.

Dietary restriction (DR) extends lifespan in an impressively wide array of species spanning three eukaryotic kingdoms. In sharp contrast, relatively little is known about the effects of DR on functional senescence, with most of the work having been done on mice and rats. Here we used Drosophila melanogaster to test the assumption that lifespan extension through DR slows down age-related...

No trade-off between learning ability and parasitoid resistance in Drosophila melanogaster

Kolss, Munjong ; Kraaijeveld, A. R. ; Mery, Frederic ; Kawecki, Tadeusz J.

In: Journal of Evolutionary Biology, 2006, vol. 19, no. 4, p. 1359-1363

Learning ability and immunity to parasites are linked at the physiological level in several insect species. The aim of this work was to investigate the relationship between learning and immunity at an evolutionary level. We tested whether selection for improved learning ability in Drosophila melanogaster led to changes in parasitoid resistance as a correlated response. Similarly, we assayed...