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Université de Fribourg

Tree shrews (Tupaia belangeri) exhibit novelty preference in the novel location memory task with 24-h retention periods

Nair, Jayakrishnan ; Topka, Marlene ; Khani, Abbas ; Isenschmid, Manuela ; Rainer, Gregor

In: Frontiers in Psychology - Cognitive Science, 2014, vol. 5, p. 303

Novelty preference is pervasive in mammalian species, and describes an inherent tendency to preferentially explore novelty. The novel location memory task studied here assesses the ability of animals to form accurate memories of a spatial configuration, consisting of several identical objects placed within an arena. Tree shrews were first familiarized with a particular object configuration during...

Université de Fribourg

Repair of the injured spinal cord, a joint approach of basic and clinical research

Buchli, Anita D. ; Rouiller, Eric M. ; Mueller, Roland ; Dietz, Volker ; Schwab, Martin E.

In: Neurodegenerative Diseases, 2007, vol. 4, no. 1, p. 51-56

The myelin protein Nogo-A is a potent inhibitor of neurite outgrowth in the central nervous system, thus contributing to the incapacity of fiber tracts in the adult spinal cord to regenerate after injury. In this review we report on a joint approach of different research groups to develop a therapy applying anti-Nogo-A antibodies to the injured spinal cord. While basic researchers took the...