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Peroxisome proliferator-activated receptor β/δ: a master regulator of metabolic pathways in skeletal muscle

Lahiri, Shawon ; Wahli, Walter

In: Hormone Molecular Biology and Clinical Investigation, 2010, vol. 4, no. 2, p. 565-573

Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue

Duteil, Delphine ; Tosic, Milica ; Lausecker, Franziska ; Nenseth, Hatice Z. ; Müller, Judith M. ; Urban, Sylvia ; Willmann, Dominica ; Petroll, Kerstin ; Messaddeq, Nadia ; Arrigoni, Laura ; Manke, Thomas ; Kornfeld, Jan-Wilhelm ; Brüning, Jens C. ; Zagoriy, Vyacheslav ; Meret, Michael ; Dengjel, Jörn ; Kanouni, Toufike ; Schüle, Roland

In: Cell Reports, 2016, vol. 17, no. 4, p. 1008–1021

Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT- selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. This shift is associated with downregulation of BAT-specific and...

Integrating complex functions: coordination of nuclear pore complex assembly and membrane expansion of the nuclear envelope requires a family of integral membrane proteins

Schneiter, Roger ; Cole, Charles N.

In: Nucleus, 2010, vol. 1, no. 5, p. 387-392

The nuclear envelope harbors numerous large proteinaceous channels, the nuclear pore complexes (NPCs), through which macromolecular exchange between the cytosol and the nucleoplasm occurs. This double-membrane nuclear envelope is continuous with the endoplasmic reticulum and thus functionally connected to such diverse processes as vesicular transport, protein maturation and lipid synthesis....

Evolutionary biology of starvation resistance: what we have learned from Drosophila

Rion, Stéphanie ; Kawecki, Tadeusz J.

In: Journal of Evolutionary Biology, 2007, vol. 20, no. 5, p. 1655-1664

Most animals face periods of food shortage and are thus expected to evolve adaptations enhancing starvation resistance (SR). Most of our knowledge of the genetic and physiological bases of those adaptations, their evolutionary correlates and trade-offs, and patterns of within- and among-population variation, comes from studies on Drosophila. In this review, we attempt to synthesize the...