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Université de Fribourg

The Evolution of Aging

Fabian, Daniel ; Flatt, Thomas

In: Nature Education Knowledge, 2011, vol. 3, no. 3, p. 1-10

Université de Fribourg

Aging and Its Demographic Measurement

Bronikowski, Anne M. ; Flatt, Thomas

In: Nature Education Knowledge, 2010, vol. 1, no. 12, p. 1-6

This case study highlights the general issues raised earlier. First, that maximum lifespan is not an easily obtainable metric. Specifically, it is unambiguous in the sense that once the last animal dies, it is most definitely dead. But to estimate the variance in maximum lifespan, many replicate populations would need to be followed for each treatment group (with each replicate providing a single...

Université de Fribourg

Diet and longevity in the balance

Flatt, Thomas

In: Nature, 2009, vol. 462, no. 24, p. 989-990

Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acids in a diet are fine-tuned, however, lifespan can be increased without loss of fecundity — at least in fruitflies.

Université de Fribourg

Drosophila germ-line modulation of insulin signaling and lifespan

Flatt, Thomas ; Min, Kyung-Jin ; D'Alterio, Cecilia ; Villa-Cuesta, Eugenia ; Cumbers, John ; Lehmann, Ruth ; Jones, D. Leanne ; Tatar, Marc

In: Proceedings of the National Academy of Sciences of the United States of America, 2008, vol. 105, no. 17, p. 6368–6373

Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not...

Université de Fribourg

Still Pondering an Age-Old Question

Flatt, Thomas ; Promislow, Daniel E. L.

In: Science, 2007, vol. 318, p. 1255-1256

A theory of trade-offs to explain why we age has spurred 50 years of interdisciplinary research in evolution and molecular genetics.

Université de Fribourg

Counting calories in Drosophila diet restriction

Min, Kyung-Jin ; Flatt, Thomas ; Kulaots, Indrek ; Tatar, Marc

In: Experimental Gerontology, 2006, vol. 42, no. 3, p. 247-251

The extension of life span by diet restriction in Drosophila has been argued to occur without limiting calories. Here we directly measure the calories assimilated by flies when maintained on full- and restricted-diets. We find that caloric intake is reduced on all diets that extend life span. Flies on low-yeast diet are long-lived and consume about half the calories of flies on high-yeast diets,...