In: Molecular oncology, 2017, vol. 11, p. 781–791
It was already in the 18th century when the French surgeon LeDran first noted that breast cancer patients with spread of tumor cells to their axillary lymph nodes had a drastically worse prognosis than patients without spread (LeDran et al., ). Since then, metastatic spread of cancer cells to regional lymph nodes has been established as the most important prognostic factor in many types of...
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In: Cancer and Metastasis Reviews, 2009, vol. 28, no. 1-2, p. 15-33
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In: Virchows Archiv, 2011, vol. 459, no. 5, p. 465-475
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In: Seminars in Cancer Biology, 2012, p. -
The ability of tumor cells to leave a primary tumor, to disseminate through the body, and to ultimately seed new secondary tumors is universally agreed to be the basis for metastasis formation. An accurate description of the cellular and molecular mechanisms that underlie this multistep process would greatly facilitate the rational development of therapies that effectively allow metastatic...
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