Université de Fribourg

Synthesis, characterization and cellular location of cytotoxic constitutional organometallic isomers of rhenium delivered on a cyanocobalmin scaffold

Santoro, Giuseppe ; Zlateva, Theodora ; Ruggi, Albert ; Quaroni, Luca ; Zobi, Fabio

In: Dalton Transactions, 2015, vol. 44, no. 15, p. 6999–7008

Constitutional isomers of cyanocobalamin adducts based on a fluorescent rhenium tris-carbonyl diimine complex were prepared, characterized and tested against PC-3 cancer cells. The adducts differ only in the relative binding position of the organometallic species which is either bound at the cyano or the 5′-hydroxo group of vitamin B₁₂. When tested for their cytotoxic potency, the species...

Université de Fribourg

Three-dimensional mid-infrared tomographic imaging of endogenous and exogenous molecules in a single intact cell with subcellular resolution

Quaroni, Luca ; Obst, Martin ; Nowak, Marcus ; Zobi, Fabio

In: Angewandte Chemie International Edition, 2014, p. -

Microscopy in the mid-infrared spectral range provides detailed chemical information on a sample at moderate spatial resolution and is being used increasingly in the characterization of biological entities as challenging as single cells. However, a conventional cellular 2D imaging measurement is limited in its ability to associate specific compositional information to subcellular structures...