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mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases

Yang, Zhihong ; Ming, Xiu-Fen

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 58–68

The continuing increase in the prevalence of obesity and metabolic disorders such as type-II diabetes and an accelerating aging population globally will remain the major contributors to cardiovascular mortality and morbidity in the 21st century. It is well known that aging is highly associated with metabolic and cardiovascular diseases. Growing evidence also shows that obesity and metabolic...