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Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro

Clift, Martin J.D. ; Frey, Sabine ; Endes, Carola ; Hirsch, Vera ; Kuhn, Dagmar A. ; Johnston, Blair D. ; Wick, Peter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: BioNanoMaterials, 2013, vol. 14, no. 3-4, p. 239-248

Cellular uptake and cell-to-cell transfer of polyelectrolyte microcapsules within a triple co-culture system representing parts of the respiratory tract

Kuhn, Dagmar A. ; Hartmann, Raimo ; Fytianos, Kleanthis ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Parak, Wolfgang J.

In: Science and Technology of Advanced Materials, 2015, vol. 16, no. 3, p. 034608

Polyelectrolyte multilayer microcapsules around 3.4 micrometers in diameter were added to epithelial cells, monocyte-derived macrophages, and dendritic cells in vitro and their uptake kinetics were quantified. All three cell types were combined in a triple co-culture model, mimicking the human epithelial alveolar barrier. Hereby, macrophages were separated in a three-dimensional model from...