Université de Fribourg

PKB/Akt-dependent regulation of inflammation in cancer

Tang, Fengyuan ; Wang, , Yuhua ; Hemmings, Brian A. ; Rüegg, Curzio ; Xue, Gongda

In: Seminars in Cancer Biology, 2017, p. -

Chronic inflammation is a major cause of human cancer. Clinical cancer therapies against inflammatory risk factors are strategically determined. To rationally guide a novel drug development, an improved mechanistic understanding on the pathological connection between inflammation and carcinogenesis is essential. PI3K-PKB signaling axis has been extensively studied and shown to be one of the...