Université de Fribourg

Modified biovectors for the tuneable activation of anti-platelet carbon monoxide release

Prieto, Lucas ; Rossier, Jeremie ; Derszniak, Katarzyna ; Dybas, Jakub ; Oetterli, René M. ; Kottelat, Emmanuel ; Chlopicki, Stefan ; Zelder, Felix ; Zobi, Fabio

In: Chemical Communications, 2017, vol. 53, no. 51, p. 6840–6843

This communication describes the anti-platelet effects of a new class of cis-rhenium(II)- dicarbonyl-vitamin B12 complexes (B12-ReCORMs) with tuneable CO releasing properties.

Université de Fribourg

Organometallic cobalamin anticancer derivatives for targeted prodrug delivery via transcobalamin-mediated uptake

Rossier, Jeremie ; Hauser, Daniel ; Kottelat, Emmanuel ; Rothen-Rutishauser, Barbara ; Zobi, Fabio

In: Dalton Transactions, 2017, vol. 46, no. 7, p. 2159–2164

Herein we report the synthesis of new water-soluble vitamin B12 prodrugs bearing metal complexes at the β-upper side of the cobalt center. A total of three derivatives with the general design {Co–C[triple bond, length as m-dash]C-bpy–M}, where M represents a cytotoxic metal complex, were prepared and tested for their cytotoxicity against MCF-7 breast cancer cells. The choice of the metal...