Université de Fribourg

N-Nitrosamine-{cis--Re[CO]₂}²⁺ cobalamin conjugates as mixed CO/NO-releasing molecules

Santoro, Giuseppe ; Beltrami, Ruben ; Kottela, Emmanuel ; Blacque, Olivier ; Bogdanova, Anna Yu. ; Zobi, Fabio

In: Dalton Transactions, 2016, vol. 45, no. 4, p. 1504–1513

Mixed CO/NO-releasing molecules were prepared by conjugation of the 17-electron rhenium dicarbonyl cis-[Re(CO)₂Br₄]²⁻ complex to N-nitrosamine modified cyanocobalamin (B12) bio-vectors. The species were fully characterized by standard analytical techniques, including X-ray crystallography for cyanocobalamin-5′-O-pyrazine and (1) and its...