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Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

Brügger, Valérie ; Duman, Mert ; Bochud, Maëlle ; Münger, Emmanuelle ; Heller, Manfred ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2017, vol. 8, p. 14272

The peripheral nervous system (PNS) regenerates after injury. However, regeneration is often compromised in the case of large lesions, and the speed of axon reconnection to their target is critical for successful functional recovery. After injury, mature Schwann cells (SCs) convert into repair cells that foster axonal regrowth, and redifferentiate to rebuild myelin. These processes require...