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Follow-up of cortical activity and structure after lesion with laser speckle imaging and magnetic resonance imaging in nonhuman primates

Peuser, Jörn ; Belhaj-Saif, Abderraouf ; Hamadjida, Adjia ; Schmidlin, Eric ; Gindrat, Anne-Dominique ; Völker, Andreas Charles ; Zakharov, Pavel ; Hoogewoud, Henri-Marcel ; Rouiller, Eric M. ; Scheffold, Frank

In: Journal of Biomedical Optics, 2011, vol. 16, no. 09, p. 096011

The nonhuman primate model is suitable to study mechanisms of functional recovery following lesion of the cerebral cortex (motor cortex), on which therapeutic strategies can be tested. To interpret behavioral data (time course and extent of functional recovery), it is crucial to monitor the properties of the experimental cortical lesion, induced by infusion of the excitotoxin ibotenic acid. In...