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Université de Fribourg

Concepts of metastasis in flux: the stromal progression model

Sleeman, Jonathan P. ; Christofori, Gerhard ; Fodde, Riccardo ; Collard, John G. ; Berx, Geert ; Decraene, Charles ; Rüegg, Curzio

In: Seminars in Cancer Biology, 2012, p. -

The ability of tumor cells to leave a primary tumor, to disseminate through the body, and to ultimately seed new secondary tumors is universally agreed to be the basis for metastasis formation. An accurate description of the cellular and molecular mechanisms that underlie this multistep process would greatly facilitate the rational development of therapies that effectively allow metastatic...