In: Nature communications, 2019, vol. 10, p. 1444
The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells is still unclear. Here we show, using mice conditionally deficient for Shp-2 in the NK lineage, that NK cell development and responsiveness are largely unaffected. Instead, we find that Shp-2 serves mainly to enforce NK cell responses to...
|
In: Oncogene, 2019, vol. 38, no. 15, p. 2814–2829
Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental...
|
In: Cellular and Molecular Life Sciences, 2011, vol. 68, no. 21, p. 3469-3478
|
In: Medical Microbiology and Immunology, 2005, vol. 194, no. 4, p. 169-174
|
In: International Immunology, 1990, vol. 2, no. 1, p. 57-62
|