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    Université de Fribourg

    Baicalein inhibits acinar-to-ductal metaplasia of pancreatic acinal cell AR42J via improving the inflammatory microenvironment

    Pu, Wei-Ling ; Luo, Ying-Ying ; Bai, Ru-Yu ; Guo, Ao-Wei ; Zhou, Kun ; Zhang, Yun-Sha ; Miao, Lin ; Rüegg, Curzio ; Hottiger, Micheal O. ; Gao, Xiu-Mei ; Sun, Li-Kang

    In: Journal of Cellular Physiology, 2018, vol. 233, no. 8, p. 5747–5755

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Recent research has demonstrated that chronic pancreatitis (CP) is associated with an increased risk of PDAC, partly due to acinar-to-ductal metaplasia (ADM). Baicalein has been shown to exert anti-inflammatory and anti-tumor effects for CP or PDAC, respectively. The aim of our study was to investigate the effect...

    Université de Fribourg

    Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

    Pu, Wei-ling ; Sun, Li-kang ; Gao, Xiu-mei ; Rüegg, Curzio ; Cuendet, Muriel ; Hottiger, Micheal O. ; Zhou, Kun ; Miao, Lin ; Zhang, Yun-sha ; Gebauer, Margaret

    In: Chinese Journal of Integrative Medicine, 2017, vol. 23, no. 10, p. 723–732

    Tumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment....