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Université de Fribourg

NGS-based S. aureus typing and outbreak analysis in clinical microbiology laboratories : Lessons learned from a Swiss-wide proficiency test

Dylus, David ; Pillonel, Trestan ; Opota, Onya ; Wüthrich, Daniel ; Seth-Smith, Helena M. B. ; Egli, Adrian ; Leo, Stefano ; Lazarevic, Vladimir ; Schrenzel, Jacques ; Laurent, Sacha ; Bertelli, Claire ; Blanc, Dominique S. ; Neuenschwander, Stefan ; Ramette, Alban ; Falquet, Laurent ; Imkamp, Frank ; Keller, Peter M. ; Kahles, Andre ; Oberhaensli, Simone ; Barbié, Valérie ; Dessimoz, Christophe ; Greub, Gilbert ; Lebrand, Aitana

In: Frontiers in Microbiology, 2020, vol. 11, p. 591093

Whole genome sequencing (WGS) enables high resolution typing of bacteria up to the single nucleotide polymorphism (SNP) level. WGS is used in clinical microbiology laboratories for infection control, molecular surveillance and outbreak analyses. Given the large palette of WGS reagents and bioinformatics tools, the Swiss clinical bacteriology community decided to conduct a ring trial (RT) to...

Université de Fribourg

Phenotypic, biochemical, and genetic analysis of kpc-41, a kpc-3 variant conferring resistance to ceftazidime-avibactam and exhibiting reduced carbapenemase activity

Mueller, Linda ; Masseron, Amandine ; Prod’Hom, Guy ; Galperine, Tatiana ; Greub, Gilbert ; Poirel, Laurent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2019, vol. 63, no. 12, p. -

A novel KPC variant, KPC-41, was identified in a Klebsiella pneumoniae clinical isolate from Switzerland. This β-lactamase possessed a 3-amino-acid insertion (Pro- Asn-Lys) located between amino acids 269 and 270 compared to the KPC-3 amino acid sequence. Cloning and expression of the blaKPC-41 gene in Escherichia coli, followed by determination of MIC values and kinetic parameters, showed...

Université de Fribourg

Klebsiella pneumoniae co-producing KPC and RmtG, finally targeting Switzerland

Mancini, Stefano ; Poirel, Laurent ; Corthesy, Myriam ; Greub, Gilbert ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2017, p. -

A carbapenem- and pan-aminoglycoside-resistant Klebsiella pneumoniae strain was isolated from a Brazilian patient hospitalized in a Swiss hospital.The clinical isolate carried genes encoding the KPC-2 carbapenemase and the RmtG 16S rRNA methyltransferase.This is the first report of a carbapenem-resistant K. pneumoniae producing RmtG in Europe

Consortium of Swiss Academic Libraries

Reply to Bastien et al

Hamad, Ibrahim ; Forestier, Claire-Lise ; Greub, Gilbert ; Jaton, Katia ; Raoult, Didier ; Bittar, Fadi

In: The Journal of Infectious Diseases, 2015, vol. 212, no. 3, p. 506-508

Consortium of Swiss Academic Libraries

Local Newspaper as a Diagnostic Aid for Psittacosis: A Case Report

Senn, Laurence ; Greub, Gilbert

In: Clinical Infectious Diseases, 2008, vol. 46, no. 12, p. 1931-1932