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Ruthenium Nanoparticles Intercalated in Hectorite: A Reusable Hydrogenation Catalyst for Benzene and Toluene

Süss-Fink, Georg ; Mollwitz, Birgit ; Therrien, Bruno ; Dadras, Massoud ; Laurenczy, Gabor ; Meister, Annette ; Meister, Götz

In: Journal of Cluster Science, 2007, vol. 18, no. 1, p. 87-95

Sawhorse-type diruthenium tetracarbonyl complexes containing porphyrin-derived ligands as highly selective photosensitizers for female reproductive cancer cells

Schmitt, Frédéric ; Auzias, Mathieu ; Štěpnička, Petr ; Sei, Yoshihisa ; Yamaguchi, Kentaro ; Süss-Fink, Georg ; Therrien, Bruno ; Juillerat-Jeanneret, Lucienne

In: JBIC Journal of Biological Inorganic Chemistry, 2009, vol. 14, no. 5, p. 693-701

Highly cytotoxic trithiophenolatodiruthenium complexes of the type [(η6- p -MeC6H4Pr i )2Ru2(SC6H4- p -X)3]+: synthesis, molecular structure, electrochemistry, cytotoxicity, and glutathione oxidation potential

Giannini, Federico ; Furrer, Julien ; Ibao, Anne-Flore ; Süss-Fink, Georg ; Therrien, Bruno ; Zava, Olivier ; Baquie, Mathurin ; Dyson, Paul ; Štěpnička, Petr

In: JBIC Journal of Biological Inorganic Chemistry, 2012, vol. 17, no. 6, p. 951-960

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

Schmitt, Frédéric ; Govindaswamy, Padavattan ; Zava, Olivier ; Süss-Fink, Georg ; Juillerat-Jeanneret, Lucienne ; Therrien, Bruno

In: JBIC Journal of Biological Inorganic Chemistry, 2009, vol. 14, no. 1, p. 101-109

Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters

Therrien, Bruno ; Ang, Wee ; Chérioux, Frédéric ; Vieille-Petit, Ludovic ; Juillerat-Jeanneret, Lucienne ; Süss-Fink, Georg ; Dyson, Paul

In: Journal of Cluster Science, 2007, vol. 18, no. 3, p. 741-752

Interaction of a ruthenium hexacationic prism with amino acids and biological ligands: ESI mass spectrometry and NMR characterisation of the reaction products

Paul, Lydia ; Therrien, Bruno ; Furrer, Julien

In: JBIC Journal of Biological Inorganic Chemistry, 2012, vol. 17, no. 7, p. 1053-1062

Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles

Mattsson, Johan ; Govindaswamy, Padavattan ; Renfrew, Anna K. ; Dyson, Paul J. ; Štěpnička, Petr ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 15, p. 4350–4357

The cytotoxicities of a new series of cationic metallarectangles have been established in the A2780 ovarian cancer cell line. Interestingly, the large rectangles incorporating 1,2-bis(4-pyridyl)ethylene linkers are ca. 5 times more cytotoxic (IC50 ≤ 6 μM) than the 4,4-bipyridine analogues (IC50 ≥ 30 μM), thus suggesting a correlation between cytotoxicity and the size...

Template-Directed Synthesis of Hexanuclear Arene Ruthenium Complexes with Trigonal-Prismatic Architecture Based on 2,4,6-Tris(3-pyridyl)triazine Ligands

Freudenreich, Julien ; Furrer, Julien ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2011, vol. 30, no. 5, p. 942–951

Cationic arene ruthenium metalla-prisms of the general formula [Ru6(p-cymene)6(3-tpt)2(OO∩OO)3]6+ (3-tpt = 2,4,6-tris(3-pyridyl)-1,3,5-triazine; OO∩OO = 5,8-dioxido-1,4-naphthoquinonato [1]6+ or 6,11-dioxido-5,12-naphthacenedionato [2]6+) have been obtained from the corresponding...

Highly Efficient NMR Enantiodiscrimination of Chiral Octanuclear Metalla-Boxes in Polar Solvent

Barry, Nicolas P.E. ; Austeri, Martina ; Lacour, Jerôme ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 16, p. 4894–4897

Detection of the molecular chirality of a series of octanuclear metalla-boxes can be readily achieved using the NMR chiral solvating agent Λ-BINPHAT in CD3CN: only 0.05 to 0.10 equiv being necessary for a complete baseline separation of some of the proton signals.

Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers

Schmitt, Frédéric ; Freudenreich, Julien ; Barry, Nicolas P.E. ; Juillerat-Jeanneret, Lucienne ; Süss-Fink, Georg ; Therrien, Bruno

In: Journal of the American Chemical Society (JACS), 2012, vol. 134, no. 2, p. 754-757

Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new strategy to tackle overall photosensitization, a limitation often encountered in photodynamic...