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The Vam6 GEF controls TORC1 by activating the EGO complex

Binda, Matteo ; Péli-Gulli, Marie-Pierre ; Bonfils, Grégory ; Panchaud, Nicolas ; Urban, Jörg ; Sturgill, Thomas W. ; Loewith, Robbie ; De Virgilio, Claudio

In: Molecular Cell, 2009, vol. 35, no. 5, p. 563-573

The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and nutrients (e.g., amino acids) and is deregulated in various cancers. Here, we report that the yeast Rag GTPase homolog Gtr1, a component of the vacuolar-membrane-associated EGO complex (EGOC), interacts with and activates TORC1 in an...