Affiner les résultats

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling

Powis, Katie ; Zhang, Tianlong ; Panchaud, Nicolas ; Wang, Rong ; Virgilio, Claudio De ; Ding, Jianping

In: Cell Research, 2015, vol. 25, no. 9, p. 1043–1059

The target of rapamycin complex 1 (TORC1) integrates various hormonal and nutrient signals to regulate cell growth, proliferation, and differentiation. Amino acid-dependent activation of TORC1 is mediated via the yeast EGO complex (EGOC) consisting of Gtr1, Gtr2, Ego1, and Ego3. Here, we identify the previously uncharacterized Ycr075w-a/Ego2 protein as an additional EGOC component that is...