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    Université de Fribourg

    Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

    Foukas, Lazaros C. ; Claret, Marc ; Pearce, Wayne ; Okkenhaug, Klaus ; Meek, Stephen ; Peskett, Emma ; Sancho, Sara ; Smith, Andrew J. H. ; Withers, Dominic J. ; Vanhaesebroeck, Bart

    In: Nature, 2006, vol. 441, p. 366-370

    The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI(3)K) family form the backbone of an evolutionarily conserved signalling pathway; however, the roles of most PI(3)K isoforms in organismal physiology and disease are unknown. To delineate the role of p110, a ubiquitously expressed...