Université de Fribourg

Impaired daily glucocorticoid rhythm in Per1Brd mice

Dallmann, Robert ; Touma, Chadi ; Palme, Rupert ; Albrecht, Urs ; Steinlechner, Stephan

In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 2006, vol. 192, no. 7, p. 769-775

Biological clocks have evolved in all kinds of organisms in order to anticipate and adjust to the daily light–dark cycle. Within the last decade, the molecular machinery underlying the circadian system was unraveled. In the present study, the impact of the loss of the Per1 or Per2 genes, key components of the core clock oscillator, on body mass, food and water intake, glucose...