Université de Fribourg

Array comparative genomic hybridization (CGH) analysis of sperm DNA to detect copy number variations in infertile men with idiopathic azoospermia

Dimova, Ivanka ; Damyanova, Vera ; Nesheva, Desislava ; Hadjidekova, Savina ; Vatev, Ilia ; Stanislavov, Romil ; Nikolova, Vesela ; Toncheva, Draga

In: Journal of Clinical Medicine and Research, 2010, vol. 2, no. 3, p. 42-48

Epididymal and testicular spermatozoa of azoospermic patients are frequently used for intracytoplasmic sperm injection (ICSI), so they must be screened for genetic abnormalities. The objective of our study was to investigate whole genome imbalances in immature germ cells found in ejaculates of six males with idiopathic azoospermia and normal karyotype. We used for the first time the most...