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Université de Fribourg

Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells

Dimova, Ivanka ; Hlushchuk, Ruslan ; Makanya, Andrew ; Styp-Rekowska, Beata ; Ceausu, Amalia ; Flueckiger, Stefanie ; Lang, Sonja ; Semela, David ; Noble, Ferdinand Le ; Chatterjee, Suvro ; Djonov, Valentin

In: Angiogenesis, 2013, p. 1–17

Notch is an intercellular signaling pathway related mainly to sprouting neo-angiogenesis. The objective of our study was to evaluate the angiogenic mechanisms involved in the vascular augmentation (sprouting/intussusception) after Notch inhibition within perfused vascular beds using the chick area vasculosa and MxCreNotch1(lox/lox) mice. In vivo monitoring combined with morphological...

Université de Fribourg

Coexistence of copy number increases of c-Myc, ZNF217, CCND1, ErbB1 and ErbB2 in ovarian cancers

Dimova, Ivanka ; Raicheva, Sashka ; Dimitrov, Rumen ; Doganov, Nikolai ; Toncheva, Draga

In: Onkologie, 2009, vol. 32, no. 7, p. 405-410

Background: We selected 5 oncogenes with well-established roles in carcinogenesis – CCND1, ErbB1, ErbB2, c-mycand ZNF217– to investigate the coexistence of their copy imbalances in relation to the clinico-pathological characteristics of ovarian tumors. Materials and Methods: Fluorescence in situ hybridization for the 5 genes was applied to a preexisting tissue microarray. 38 ovarian tumors...

Université de Fribourg

Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy

Templin, Christian ; Meyer, Martin ; Müller, Maja Franziska ; Djonov, Valentin ; Hlushchuk, Ruslan ; Dimova, Ivanka ; Flueckiger, Stefanie ; Kronen, Peter ; Sidler, Michele ; Klein, Karina ; Nicholls, Flora ; Ghadri, Jelena-Rima ; Weber, Klaus ; Paunovic, Dragica ; Corti, Roberto ; Hoerstrup, Simon P. ; Lüscher, Thomas F. ; Landmesser, Ulf

In: European Heart Journal, 2010, vol. 31, no. 14, p. 1792-1801

Aims Coronary late stent thrombosis, a rare but devastating complication, remains an important concern in particular with the increasing use of drug-eluting stents. Notably, pathological studies have indicated that the proportion of uncovered coronary stent struts represents the best morphometric predictor of late stent thrombosis. Intracoronary optical frequency domain imaging (OFDI), a novel...

Université de Fribourg

Array comparative genomic hybridization (CGH) analysis of sperm DNA to detect copy number variations in infertile men with idiopathic azoospermia

Dimova, Ivanka ; Damyanova, Vera ; Nesheva, Desislava ; Hadjidekova, Savina ; Vatev, Ilia ; Stanislavov, Romil ; Nikolova, Vesela ; Toncheva, Draga

In: Journal of Clinical Medicine and Research, 2010, vol. 2, no. 3, p. 42-48

Epididymal and testicular spermatozoa of azoospermic patients are frequently used for intracytoplasmic sperm injection (ICSI), so they must be screened for genetic abnormalities. The objective of our study was to investigate whole genome imbalances in immature germ cells found in ejaculates of six males with idiopathic azoospermia and normal karyotype. We used for the first time the most powerful...