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EEF1A1 deacetylation enables transcriptional activation of remyelination

Duman, Mert ; Vaquié, Adrien ; Nocera, Gianluigi ; Heller, Manfred ; Stumpe, Michael ; Sankar, Devanarayanan Siva ; Dengjel, Jörn ; Meijer, Dies ; Yamaguchi, Teppei ; Matthias, Patrick ; Zeis, Thomas ; Schaeren-Wiemers, Nicole ; Hayoz, Antoinette ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2020, vol. 11, no. 1, p. 3420

Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1...

Multiple roles of class I HDACs in proliferation, differentiation, and development

Reichert, Nina ; Choukrallah, Mohamed-Amin ; Matthias, Patrick

In: Cellular and Molecular Life Sciences, 2012, vol. 69, no. 13, p. 2173-2187

Gene Structure and Characterization of the Murine Homologue of the B Cell-Specific Transcriptional Coactivator OBF-1

Schubart, Daniel B. ; Sauter, Patrick ; Massa, Steffen ; Friedl, Erika M. ; Schwarzenbach, Heidi ; Matthias, Patrick

In: Nucleic Acids Research, 1996, vol. 24, no. 10, p. 1913-1920

Correlation of anti-viral B cell responses and splenic morphology with expression of B cell-specific molecules

Fehr, Thomas ; López-Macías, Constantino ; Odermatt, Bernhard ; Torres, Raul M. ; Schubart, Daniel B. ; O'Keefe, Theresa L. ; Matthias, Patrick ; Hengartner, Hans ; Zinkernagel, Rolf M.

In: International Immunology, 2000, vol. 12, no. 9, p. 1275-1284

HDAC1 and HDAC2 Control the specification of neural crest cells into peripheral glia

Jacob, Claire ; Lötscher, Pirmin ; Engler, Stefanie ; Baggiolini, Arianna ; Tavares, Sandra Varum ; Brügger, Valérie ; John, Nessy ; Büchmann-Møller, Stine ; Snider, Paige L. ; Conway, Simon J. ; Yamaguchi, Teppei ; Matthias, Patrick ; Sommer, Lukas ; Mantei, Ned ; Suter, Ueli

In: The Journal of Neuroscience, 2014, vol. 34, no. 17, p. 6112–6122

Schwann cells, the myelinating glia of the peripheral nervous system (PNS), originate from multipotent neural crest cells that also give rise to other cells, including neurons, melanocytes, chondrocytes, and smooth muscle cells. The transcription factor Sox10 is required for peripheral glia specification. However, all neural crest cells express Sox10 and the mechanisms directing neural crest...