Université de Fribourg

The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis

Schnell, Anna ; Chappuis, Sylvie ; Schmutz, Isabelle ; Brai, Emanuele ; Ripperger, Jürgen A. ; Schaad, Olivier ; Welzl, Hans ; Descombes, Patrick ; Alberi, Lavinia ; Albrecht, Urs

In: PLoS ONE, 2014, vol. 9, no. 6, p. e99883

The function of the nuclear receptor Rev-erbα (Nr1d1) in the brain is, apart from its role in the circadian clock mechanism, unknown. Therefore, we compared gene expression profiles in the brain between wild-type and Rev-erbα knock-out (KO) animals. We identified fatty acid binding protein 7 (Fabp7, Blbp) as a direct target of repression by REV-ERBα. Loss of Rev-erbα manifested in memory and...