Université de Fribourg

Calretinin regulates Ca²⁺-dependent inactivation and facilitation of Cav2.1 Ca²⁺ channels through a direct interaction with the α₁2.1 subunit

Christel, Carl J. ; Schaer, Raphael ; Wang, Shiyi ; Henzi, Thomas ; Kreiner, Lisa ; Grabs, Detlev ; Schwaller, Beat ; Lee, Amy

In: Journal of Biological Chemistry, 2012, p. -

Voltage-gated Cav2.1 Ca2+ channels undergo dual modulation by Ca2+, Ca2+-dependent inactivation (CDI) and facilitation (CDF), which can influence synaptic plasticity in the nervous system. While the molecular determinants controlling CDI and CDF have been the focus of intense research, little is known about the factors regulating these processes in neurons. Here, we show that calretinin (CR), a...

Université de Fribourg

Compensatory Regulation of Cav2.1 Ca²⁺ Channels in Cerebellar Purkinje Neurons Lacking Parvalbumin and Calbindin D-28k

Kreiner, Lisa ; Christel, Carl J. ; Benveniste, Morris ; Schwaller, Beat ; Lee, Amy

In: Journal of Neurophysiology, 2010, vol. 103, p. 371-381

Cav2.1 channels regulate Ca²⁺ signaling and excitability of cerebellar Purkinje neurons. These channels undergo a dual feedback regulation by incoming Ca²⁺ ions, Ca²⁺-dependent facilitation and inactivation. Endogenous Ca²⁺-buffering proteins, such as parvalbumin (PV) and calbindin D-28k (CB), are highly expressed in Purkinje neurons and therefore may influence...