Université de Fribourg

Calretinin regulates Ca²⁺-dependent inactivation and facilitation of Cav2.1 Ca²⁺ channels through a direct interaction with the α₁2.1 subunit

Christel, Carl J. ; Schaer, Raphael ; Wang, Shiyi ; Henzi, Thomas ; Kreiner, Lisa ; Grabs, Detlev ; Schwaller, Beat ; Lee, Amy

In: Journal of Biological Chemistry, 2012, p. -

Voltage-gated Cav2.1 Ca2+ channels undergo dual modulation by Ca2+, Ca2+-dependent inactivation (CDI) and facilitation (CDF), which can influence synaptic plasticity in the nervous system. While the molecular determinants controlling CDI and CDF have been the focus of intense research, little is known about the factors regulating these processes in neurons. Here, we show that calretinin (CR), a...

Université de Fribourg

Expression of SV2 in the developing chick cerebellum: comparison with Calbindin and AMPA glutamate receptors 2/3

Grabs, Detlev ; Escher, Lukas ; Bergmann, Mathias

In: The Anatomical Record, 2008, vol. 291, no. 5, p. 538 - 546

The well-organized cerebellum is an ideal model to investigate the developmental appearance and localization of pre- and postsynaptic structures. One of the synaptic proteins abundant in the central nervous system and localized in presynaptic vesicle membranes is the synaptic vesicle protein 2 (SV2). SV2 was shown to be involved in priming and modulating synaptic vesicles and having an effect in...