Université de Fribourg

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Pu, Wei-ling ; Sun, Li-kang ; Gao, Xiu-mei ; Rüegg, Curzio ; Cuendet, Muriel ; Hottiger, Micheal O. ; Zhou, Kun ; Miao, Lin ; Zhang, Yun-sha ; Gebauer, Margaret

In: Chinese Journal of Integrative Medicine, 2017, vol. 23, no. 10, p. 723–732

Tumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment....

Université de Fribourg

Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana

Ndongo, Joseph T. ; Issa, Mark E. ; Messi, Angelique N. ; Mbing, Joséphine Ngo ; Cuendet, Muriel ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G.

In: Natural Product Research, 2015, vol. 29, no. 17, p. 1684-1687

Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3′,4′-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D- fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem...