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Université de Fribourg

Prognostic value of troponin I for infarct size to improve preclinical myocardial infarction small animal models

Frobert, Aurélien ; Valentin, Jérémy ; Magnin, Jean-Luc ; Riedo, Erwin ; Cook, Stéphane ; Giraud, Marie-Noëlle

In: Frontiers in Physiology - Clinical and Translational Physiology, 2015, vol. 6, p. 353

Coronary artery ligations to induce myocardial infarction (MI) in mice and rats are widely used in preclinical investigation. However, myocardial ischemic damage and subsequent infarct size are highly variable. The lack of standardization of the model impairs the probability of effective translation to the clinic. Cardiac Troponin I (cTnI) is a major clinically relevant biomarker.Aim: In the...