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A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat

Boyer, Frédéric ; Balado, Eric ; Piazza, Pier V. ; Dreyer, Jean-Luc ; Deroche-Gamonet, Véronique

In: Addiction Biology, 2011, vol. 16, no. 1, p. 120–123

Except as a marker of cancer progression, gamma-synuclein (GSyn) had received little attention. Recent data showed however that GSyn modulates cocaine-induced locomotor effects, suggesting that it could also play a role in cocaine reinforcing effects. In the rat, siRNAs targeting GSyn expression were injected in the nucleus accumbens and cocaine reinforcing effects were evaluated by means of...