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Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

Sovari, Sara Nasiri ; Vojnovic, Sandra ; Bogojevic, Sanja Skaro ; Crochet, Aurélien ; Pavic, Aleksandar ; Nikodinovic-Runic, Jasmina ; Zobi, Fabio

In: European Journal of Medicinal Chemistry, 2020, vol. 205, p. 112533

We have prepared a series of ten 3-arylcoumarin molecules, their respective fac- [Re(CO)3(bpy)L]+ and fac-[Re(CO)3(L⁀L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) > 150 μM, when coordinated to the fac-[Re(CO)3]+ core,...

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Antiplasmodial activity and in vivo bio-distribution of chloroquine molecules released with a 4-(4-ethynylphenyl)-triazole moiety from organometallo-cobalamins

Rossier, Jeremie ; Sovari, Sara Nasiri ; Pavic, Aleksandar ; Vojnovic, Sandra ; Stringer, Tameryn ; Bättig, Sarah ; Smith, Gregory S. ; Nikodinovic-Runic, Jasmina ; Zobi, Fabio

In: Molecules, 2019, vol. 24, no. 12, p. 2310

We have explored the possibility of using organometallic derivatives of cobalamin as a scaffold for the delivery of the same antimalarial drug to both erythro- and hepatocytes. This hybrid molecule approach, intended as a possible tool for the development of multi-stage antimalarial agents, pivots on the preparation of azide- functionalized drugs which, after coupling to the vitamin, are...

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